It runs from 4am on Friday, August 21, until 6pm that evening, with the whole of the region, most of England, all of Wales and the south of Scotland covered by the alert.
The wind will follow Storm Ellen, which will sweep across the north of Ireland tonight, Wednesday, August 19, before dominating the weather for the remainder of the week.
Notice that some coastal areas will be affected by spray and large waves is noted in the warning.
The Met Office said: “There will be strong southwesterly winds are expected to develop across much of England, Wales and southern Scotland during Friday.
"Wind gusts of 45 to 50 mph are expected fairly widely inland with gusts of 55 to 60 mph possible around coasts and over hills.
"Winds are then expected to gradually ease during late afternoon and evening.”
It has warned the region should expect some travel disruption, with a chance some bus and train services will be affected. Some journeys could also take longer.
Delays for high-sided vehicles on exposed routes and bridges are possible and it warns there could be a short term loss of power and other services.
It adds: “It’s likely that some coastal routes, sea fronts and coastal communities are affected by spray and/or large waves
“Some damage to trees with debris on roads are possible given the time of year.”