With Northumberland being so close to the border there are bound to be strong feelings and, quite possibly, some divided loyalties.
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Here’s all you need to know about the Six Nations fixture
Kick-off time: 4.50pm
Where? BT Murrayfield Stadium, Edinburgh
Live coverage: BBC 1 from 4.25pm and Radio 5 Live from 4.50pm
Scotland team: Stuart Hogg, Sean Maitland, Mark Bennett, Matt Scott, Tommy Seymour, Finn Russell, Greig Laidlaw; Al Dickinson, Ross Ford, WP Nel, Richie Gray, Jonny Gray, John Barclay, John Hardie, David Denton. Replacements: Stuart McInally, Gordon Reid, Zander Fagerson, Tim Swinson, Blair Cowan, Sam Hidalgo-Clyne, Duncan Weir, Duncan Taylor.
England team: Mike Brown; Anthony Watson, Jonathan Joseph, Owen Farrell, Jack Nowell; George Ford, Danny Care; Billy Vunipola, James Haskell, Chris Robshaw; George Kruis, Joe Launchbury; Dan Cole, Dylan Hartley, Joe Marler. Replacements: Jamie George, Mako Vunipola, Paul Hill, Courtney Lawes, Jack Clifford, Ben Youngs, Alex Goode, Ollie Devoto.
Odds: Scotland 9/4 Draw 18/1 England 4/9
Last five meetings: England 25-13 Scotland; Scotland 0-20 England; England 38-18 Scotland; Scotland 6-13 England; England 22-16 Scotland.
Ones to watch: WP Nel, Johnny Gray, Finn Russell (Scotland); Joe Marler, Danny Care, Owen Farrell (England).
What they’re saying: “It’s England, it’s a big rivalry, you always want to go out and beat them, especially because it is so close to home. It’s just a big game and coming through the age groups they have always had the edge on us. I don’t think I’ve beaten England at age group rugby so I really want to go out and get a win against them this week.” - Scotland centre Mark Bennett
“We are confident we can go to Edinburgh and win, but we’re in no doubt it will be a huge challenge. Playing at Murrayfield in front of a passionate Scottish crowd will be a real test for this team but one I know we can rise to.
“There were some tight calls on selection, but we have picked a match-day squad with a blend of experience and youth.” - England coach Eddie Jones