Police, fire and ambulance crews were called to the B1340 between Longhoughton and Denwick after a collision between a van and a lorry at the Harlow Hill Farm junction.
The road has been closed in both directions and police are currently diverting traffic.
It is believed the Great North Air Ambulance is also on the scene.
Vehicles travelling between Denwick and Longhoughton are advised to go along the A1 and A1068 via Lesbury.
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