The events in Alnwick, Hexham, Ashington and North Seaton will all start at 10am and finish at noon this Friday.
The clean-ups will take place in Hexham - meet on Maiden's Walk near to junction with Allen Drive; Alnwick - meet outside Alnwick News shop on Upper Barresdale; Ashington - colliery rows between Milburn Road and Hawthorn Road - meet on Milburn Road close to entrance to Central First School; North Seaton - Paddock Woods North Seaton Roundabout to Woodhorn roundabout - meet at woods near to North Seaton roundabout.
Launched this year, The Great British Spring Clean is a national clean-up weekend running from March 3 to 5.
Coun Ian Swithenbank, cabinet member for local services, said: "The spring clean is a great chance for people to work together to help improve their neighbourhoods. We are urging residents to spare just a couple of hours of their time on Friday and come out and get involved."
Litter remains a huge problem across the country, causing harm to the environment and wildlife, with councils in England having to spend more than £700million on street-cleaning services every year.
There are also a number of other neighbourhood clean-ups taking place across the county and the council will be also be supporting these by providing litter pickers, hi-vis vests, gloves and rubbish bags as well as picking up the refuse afterwards. For more information, contact [email protected]