The motorcyclist has been airlifted to hospital in Newcastle with injuries not believed to be life threatening.
The road has since re-opened.
A Northumbria Police spokesperson said: “At about 2.40pm today (Tuesday), we received a report of a collision involving a van and a motorcycle on Renwick Road in Blyth.
“The motorcyclist, a man in his 20s, has been airlifted to the RVI, with injuries that are not believed to be life threatening.
“The road has now re-opened.”