Road Safety GB North East (RSGB NE) has been joined by police, fire and Newcastle Sunderland and Middlesbrough football clubs to urge people not to get behind the wheel after drink or drugs during the football championships.
Officials say drink and drug driving typically increases during major sporting tournaments as people gather to watch the games over drinks.
During Euro 2016, there was an increase in drink and drug driving injuries in the region.
Peter Slater, from Road Safety GB NE, said: “We know people are looking forward to the Euros and have lots of plans to meet up with friends and family to watch the games."
“It’s been a long time coming and we don’t want to spoil the fun, but we’re asking people to be sensible.
"If you know you’re going to be drinking, plan your transport home beforehand, or be the designated driver. If you’re driving, stick to soft drinks.”
Superintendent Sam Rennison, of Northumbria Police, said: “We know that more people are likely to be enjoying a drink as they watch the drama of the Euros unfold.
“But our message to fans is a simple one – don’t get behind the wheel of a car when you’ve been drinking or using drugs.”
A Newcastle United FC spokesperson said: “We fully support Road Safety GB North East's campaign.
"For anyone heading out to watch the Euros and planning to have a drink, we urge you to leave your car at home.”