Four churches in Bamburgh, Rothbury, Alnmouth and Craster have been broken into over the last two months.
On Monday, two visitors to St Peter the Fisherman, in Craster, discovered the church had been ransacked. They found the door unlocked and thought someone was working in the church.
Thieves had pulled out two pews to get into hidden cupboards, vandalised the altar area and left a tap running in the church.
Churchwarden Doris Clarke said: "The church is over 100 years old. No money was in there apartfrom a little charity box in the passage. It is missing now, so that was probably what they were looking for.
She added that all the cupboards in the church had been ransacked and the vicar's clothes had been left in a heap. A joiner was called to fix the door which had been jemmied open by the thieves.
Rev Micheal Mountney, vicar at St Peter's said: "For the effort they put in they must have got nothing back. It is a pity that they haven't learnt their lesson.
"I am just relieved that nothing of real value was stolen and that the damage was easy to repair. We are being very vigilant and taking all reasonable precautions – we don't leave money lying about anyway."
At St John's Church in Alnmouth, thieves attempted to break in to the vestry of the church, sometime between Sunday, May 4, and Thursday, May 8, but were unsuccessful. Damage was caused to the door and the lock, but nothing was stolen.
The Gazette reported last month how cash was stolen from donation bottles at All Saints' Church in Rothbury when about £30 was stolen from the church. And St Aidan's church in Bamburgh was broken into on March 29.
Neighbourhood inspector Sue Peart said: "It is very concerning that places of worship are being targeted, which is pretty despicable. We want people to be free to go into churches."
She added that in some cases churches were being targeted after funeral services and added: "How vile is a person that does that kind of thing, it is absolutely sickening and we are doing everything we can to catch the perpetrators."
A new scheme called Faith Watch is being set up by the police and managed by neighbourhood beat managers to make churches in the district harder to target.
Anyone with information about the thefts should contact police on 03456 043 043.